Episode 26: [Interview] The Gut-Brain Axis with Kiran Krishnan

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This Week Sinclair spoke with Kiran Krishnan, a microbiologist who co-founded “Microbiome Labs”. Instead of waiting to treat you when you become severely ill, Kiran will teach you simple lifestyle changes that can have drastic effects on your lifelong health by understanding our place in nature and the balance of our own gut biome.

The Gut-Brain Axis with Kiran Krishnan

We have created a world that is “Anti-human”

In this episode, Sinclair speaks with Microbiologist  Kiran Krishnan, Co-founder of “Microbiome Labs”

He will teach you what the Microbiome is, what has caused it to become imbalanced and how you can take simple steps to heal your gut.

Instead of focusing on symptoms, today’s episode explores daily changes that can prevent diseases from forming in the body.

Regardless of what stage of healing you are in, Karin teaches us that ,We are not the disease. Most sickness comes from lifestyle so by the same logic we can regain our health through lifestyle as well.


  • [5:28] Microbiome Labs 
  • [7:24] The Folly of Marketing driven product development
  • [10:39] We are dealing with an explosion of chronic conditions 
  • [13:09] What are Lifestyle disorders?
  • [15:00] Leaky gut is the main source of inflammation
  • [19:45] The 3 main causes of chronic diseases: roundup, antibiotics and disconnection from the natural microbial environment
  • [28:00] How to navigate all the conflicting information
  • [33:45] Simple changes for profound effects: Intermittent fasting, probiotics, reducing inflammation, diversifying your diet and mindfulness
  • [40:00] The Gut Brain Axis: how our prolonged Fight or Flight response is harming us
  • [47:00] Peptidoglycan and child development
  • [50:00] Zen Biome: reducing neural inflammation 
  • [52:00] Functional medicine: rebuilding the foundation by addressing the root cause 

Memorable Quotes:

  • [11:25] “Prior to the initiation of the “Human Genome Project” the assumption was that for every chronic illness that we deal with, we are going to find a gene that’s driving it. That chronic illness was largely driven by genetic mishaps. If you have heart disease you have a heart disease gene, if you have a cancer of some sort you have a cancer gene, and sure genetics play some component of it but it’s a much more MINOR component than we ever imagined”  
  • [12:17] “The big question is “How are we this sophisticated?” Well, that's because we harbor 2.5 million microbial genes in our system. So we have 150-200 times more microbial genetic material in our system that we use to function as a human, then we have human genes."   
  • [16:30] “Over the last 4 million years We’ve evolved to be WITHIN nature. We are supposed to be in this constant osmosis with the natural environment, we’re shedding organisms, we’re picking up organisms, we’re picking up genetic material and proteins and peptides, and all of these things from the natural world but then we’ve gone and divorced from it."
  • [27:19] “Absence is just as bad as deliberate toxicity” 
  • [29:13] “Lack of hope has a huge impact on your microbiome which increases inflammation and that will actually perpetuate the condition.” 
  • [30:04] “You are NOT your illness, people define themselves by the illness that they have suffered from for years and that is a manifestation of the illness in itself. I meet lots of people where they should basically introduce themselves like “Hi my name is Sibo” or “Hi, my name is Eczema” because that’s their whole identity. And I understand it but they need to detach themselves from that illness. That illness is a temporary thing and it will get better, so don’t embrace it as part of your identity.”  

Where to find the Guest:


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DISCLAIMER: The information contained in this podcast is for educational purposes only and is not intended to treat, diagnose, cure, or prevent any disease. You should always seek the advice of your physician or otherwise qualified healthcare provider with any questions you have regarding a medical condition before undertaking any diet, exercise, supplement, health program, or other procedures discussed in this podcast